Abstract
Serum level of hyaluronate (HA) was assayed by an affino-immunoenzymatic method using hyaluronectin, in 25 patients with rheumatoid arthritis (RA), 24 patients with ankylosing spondylitis (AS) and 103 controls. The mean serum HA level was significantly higher (p less than 0.001) in RA (171 +/- 39 micrograms/l) than in controls (22.4 +/- 1.6 micrograms/l) and AS patients (30.3 +/- 3.0 micrograms/l). The mean HA level in RA on corticosteroids (98.2 +/- 25.9 micrograms/l) was significantly lower (p less than 0.05) than that of RA without steroids (220.1 +/- 60.5 micrograms/l). The serum HA levels were not correlated with clinical or serological indicators of inflammatory activity. This increase in serum HA probably reflected an excessive production by rheumatoid synovium and not a lowered catabolism, all patients having normal hepatic function. The origin of the increased synthesis is still unknown. These results suggest that serum hyaluronate is not a universal indicator of inflammation but is perhaps a characteristic of RA.
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