Abstract
The blood–brain barrier (BBB) functions to protect the brain from potentially-damaging pathogens and limits the infiltration of peripheral immune cells. It is a complex arrangement of astrocytes and endothelial cells which forms tight junctions and gives the structure its barrier properties. Recent evidence has highlighted the presence of peripheral immune cells in the brain parenchyma of a mouse model of Alzheimer's disease (AD; APP/PS1 mice) while disruption of the BBB and transendothelial migration of peripheral leukocytes have been reported in neuroinflammatory diseases.
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