Abstract
Research in the field of growth and growth factors has produced outstanding achievements in basic science which may represent the premises for future translations into clinical practice. Particularly the role of the IGF system in the central nervous system has been extensively and successfully investigated, yielding preliminary results which are not only functional for understanding physiology but also potentially useful for future clinical applications. New evidence suggests a role of IGFs in the emerging field of molecular mechanisms of endoplasmic reticulum stress response which is involved in the processes of chronic inflammation, diabetes and atherosclerosis. The availability of new genetic technologies has enabled to dissect the action of GH from that of IGF-I in mammalian skeletal muscle, thus opening an avenue for more targeted interventions for attenuating muscle loss and influencing insulin sensitivity and global nutrient metabolism. In this selection of studies, which obviously represents my own bias, I have tried to provide the reader with the most provocative, promising, controversial and enjoyable research papers published in the last year.
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