Abstract
PURPOSE: Sarcoidosis is a multisystemic granulomatous disorder of unknown etiology. The unpredictable clinical course of the disease has prompted research into biomarkers useful for predicting outcome. Among the potential markers of sarcoidosis, a recently proposed indicator was chitotriosidase, a chitinase produced by activated macrophages. In 2007 chitotriosidase activity was analyzed for the first time in a group of 96 patients with sarcoidosis in order to assess chitotriosidase specificity as a marker of sarcoidosis.((Bargagli E et al. Respiration 2007; 74: 548-552). In this study we wanted to evaluate value of chitotriosidase as a marker of sarcoidosis activity in our patients.
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