Abstract
Neuroinflammation is a key pathophysiological hallmark in amyotrophic lateral sclerosis (ALS), which seems to be linked to the disease progression. Cerebrospinal fluid (CSF) chitinase-3-like protein 1 (CHI3L1), a marker of glial activation, is a recent candidate biomarker of ALS, but less is clear about its value in the serum. In this study, we explore if serum CHI3L1 could add prognostic value as biomarker of ALS.
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