Abstract
e21054 Background: The usefulness of tumor markers in NSCLC is not well defined. High levels of CEA are considered a negative prognostic factor in early-stages NSCLC but its role in advanced disease is yet to be defined. The aim of the study is to analyze the prognostic value of basal level of CEA in unselected NSCLC patients. Methods: 320 NSCLC patients diagnosed in our institution between April 2004 and March 2009 were retrospectively reviewed. Baseline prognostic factors analyzed were gender, histology, clinical stage and brain metastases. Overall survival (OS), disease-free survival (DFS) and progression-free survival (PFS) were calculated by the Kaplan-Meier method. The cutoff value of serum CEA level was 5 ng/mL. Results: Baseline patients characteristics: median age 63 (30-82 years), males 84.4%, stage I: 7.2%, II: 6.3%, III: 33% and IV 53%; squamous carcinoma 23.8%, adenocarcinoma 39.7%, large cell carcinoma 19.4% and undifferentiated carcinoma 15%. High levels of CEA were detected in 179 (56.5%) patients. Significant higher levels of CEA at baseline were present in adenocarcinoma (p = 0.03) and patients with advanced disease (p = 0.01) but not difference according sex or brain metastases were detected. After a follow-up of 9.7 months, 256 patients relapsed and 202 patients had died. In the 275 patients with advanced disease, the PFS was 5.3 months vs 7.4 months for patients with high and normal CEA (p = 0.011) and the OS 10.0 months vs 14.0 months in patients with high and normal CEA (p = 0.085). In early stages (I-II) the DFS was 14.2 vs 20.3 months (p = 0.141) and OS 35 vs 47.7 months (p = 0.045) for patients with high and normal CEA. In the multivariate analysis only high levels of CEA, histology and stage were significant correlated with worse prognostic. Conclusions: In our analysis, high levels of CEA at baseline are correlated with worse survival in stage I-IV NSCLC patients. No significant financial relationships to disclose.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
