Abstract
Objective: The objective of this study was to compare serum calcium, magnesium and Parathyroid hormone in preeclamptic women and normal pregnant females. Materials and Methods: 32 pregnant women, preeclamptic n=16 and healthy pregnant control group n=16 with same ages and period of gestation included in present study. Serum calcium, Magnesium and Parathyroid Hormone were done by standard methods. Data are presented as mean ± SEM. P value < 0.01 was considered statistically significant. Results: Serum calcium (7.02 ± 0.99 vs. 9.34 ± 0.57) and serum magnesium (1.3 ± 0.34 vs1.88 ± 0.16) was significantly lower in preeclamptic women than normal healthy controls. PTH (Intact) concentration was not changed as compare to normal control (24.07 ± 4.98 vs. 23.86 ± 3.30). Conclusion: Decreased levels of serum Calcium and serum Magnesium found in our study confirms there strong relation with preeclampsia. Calcium and magnesium supplement can be used in pregnant women for the prevention of preeclampsia.
Highlights
Pre-eclampsia (PE) is the most common life-threatening hypertensive disorder of pregnancy, define as a systemic syndrome characterized by hypertension, proteinuria and edema after 20 weeks of gestation [1,2,3]
Decreased levels of serum Calcium and serum Magnesium found in our study confirms there strong relation with preeclampsia
Calcium and magnesium supplement can be used in pregnant women for the prevention of preeclampsia
Summary
Pre-eclampsia (PE) is the most common life-threatening hypertensive disorder of pregnancy, define as a systemic syndrome characterized by hypertension, proteinuria and edema after 20 weeks of gestation [1,2,3]. Pathophysiology of PE is still unclear and it becomes apparent at the late stages of pregnancy, usually in the third trimester [1,4]. It is the leading global cause of maternal and perinatal mortality and approximately 50,000 to 60,000 women die each year out of which 9% of maternal deaths in Asia [1,5]. High incidence of pre-eclampsia was shown in Pakistani studies [4,6]
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