Serum adiponectin level in patients with diabetic foot

Abstract

Objective To study the serum adiponectin level in diabetic foot patients and to analysis its biological mechanisms. Methods From January 2008 to December 2010, 85 patients with diabetes mellitus (DM) were enrolled, including 55 patients with diabetic foot (DF)(30 non-gangrenous cases and 25 gangrenous cases) and 30 without diabetic foot. Thirty age- and gender-matched healthy volunteers were served as controls. Clinical characteristics such as body mass index(BMI), fasting plasma glucose(FPG), glycosylated hemoglobin A1c(HbA1c), high-density lipoprotein cholesterol(HDL-C), high sensitive C-creactive protein(hsCRP), urinary albumin excretion rate (UAER), ankle-brachial index(ABI), and intima-media thickness (IMT)were recorded. Serum level of adiponectin was measured by ELISA. Influences of statins treatment on serum level of adiponectin were compared between DM and DF groups. Differences of means between groups were compared by One-way ANOVA. Correlations between serum adiponectin and other parameters were analyzed by Pearson's correlation and multivariate stepwise regression. Results Serum adiponectin levels were higher in DF patients than DM patients and controls ((9.7±5.3)vs(5.4±2.8) and (8.3±3.4)mg/L, F=8.65, P 0.05). In DF group, the correlation analysis indicated that adiponectin level was negatively correlated with BMI (r=-0.314)and HbA1c(r=-0.329), while positively correlative with UAER (r=0.401), IMT(r=0.360) and HDL-C(r=0.441)(all P<0.05). In multivariate stepwise regression analysis, HDL-C and UAER were independent factors of serum adiponectin. Conclusion Serum adiponectin level was significantly increased in DF patients. HDL-C and UAER may be independent factors of serum adiponectin. Key words: Diabetes mellitus, type 2; Diabetic foot; Adiponectin; Albuminuria; Statins