Abstract
ObjectiveTo evaluate whether serum adipocytokine concentrations, controlling for baseline adiposity, are predictive of adipose weight gain in adolescents initiating depot medroxyprogesterone acetate (DMPA). MethodsPercent body fat was measured at baseline and 6 months. Baseline serum adipocytokine concentrations were quantified. ResultsMean percent body fat was 31.6% (±7.6) at baseline and 33.5% (±7.6) at 6 months. In multivariable linear regression modeling (adjusted for baseline percent body fat), Hispanic ethnicity and baseline serum adiponectin concentration were inversely associated (p≤.05) with absolute change in percent body fat at 6 months. ConclusionsSerum adiponectin concentration may be useful for assessing risk of DMPA-associated adipose gains.
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