Abstract
Adenosine deaminase (ADA) catalyzes the conversion of adenosine to inosine. Since it was reported that two children with severe combined immunodeficiency lacked any detectable ADA activity in their red blood cells, a renewed interest has been focused on the role of ADA in the immunological system [1,2]. Furthermore, determination of ADA activity in serum and pleural fluid has found a wider clinical application in establishing the diagnosis of patients with pleural effusion stemming from many different disorders [3-51. A well-known example of these observations is that of the high ADA activity of tuberculosis in adults [3,6]. ADA activity of tuberculosis in children, however, has not been investigated, and there has been no longitudinal study of ADA activity vis-a-vis advancing age. The purpose of this paper is to establish the normal serum ADA activity value in children and to evaluate the usefulness of ADA value in diagnosing respiratory diseases.
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