Abstract
The 5-HT1A receptor gene (HTR1A) polymorphisms have been implicated in the etiology of major depressive disorder and in the therapeutic response to selective serotonin reuptake inhibitors (SSRIs). Previous studies have investigated the potential association of a functional HTR1A C-1019G polymorphism (rs6295C/G) in the promoter region with SSRIs pharmacogenetics in Caucasian (Serretti et al., 2004; Parsey et al., 2006; Levin et al., 2007), Japanese (Kato et al., 2009), and Chinese (Hong et al., 2006); however, the results have been inconsistent. In addition, Kato et al. (2009) found that two nonsynonymous polymorphisms (rs10042486C/T and rs1364043G/ T) were associated with greater response to antidepressants in Japanese. In this study, we investigated whether these three HTR1A polymorphisms are related to the antidepressant effects of sertraline (Zoloft) in ChineseHan patients.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
