Abstract
We report a fast, one-step, facile, and green preparation method that yields very stable and biocompatible silver colloids that are highly active as surface-enhanced Raman spectroscopy (SERS) platforms that has a possible application in biomedicine. Reduction of silver nitrate has been carried out using polyethylene glycol (PEG) which acts as both reducing agent and stabilizer. It turned out that the -OH groups provided by the addition of NaOH represent a key element in the successful synthesis of PEG-coated silver nanoparticles (AgNPs). The as-obtained silver colloids have been characterized by UV-visible spectroscopy, transmission electron spectroscopy, and SERS using 532- and 633-nm laser lines on a dispersive Raman spectrometer. Several analytes as methylene blue, p-aminothiophenol, amoxicillin, and Cu(PAR)2 were used to prove SERS enhancement of the obtained silver colloid. It has been found that the PEGylated AgNPs provide SERS signals comparable to those achieved using classical hydroxylamine and citrate-reduced silver colloids, thus demonstrating the ability of this new method to prepare biocompatible silver colloids.
Highlights
Since its discovery in 1974, surface-enhanced Raman spectroscopy (SERS) has become a widely used analytical technique offering many advantages over other techniques such as FT-IR spectroscopy, UV-visible-near infrared (UV–vis-NIR) absorption, X-ray photoelectron spectroscopy, mass spectrometry, etc
The UV–vis spectra recorded on a sample taken straight after the color shift exhibit a peak located close to 400 nm, providing the existence of PEGreduced Silver nanoparticles (AgNPs) in the solution
We propose an easy, fast, one-step, facile, and green method for the synthesis of silver nanoparticles improving the straightforward creation of functionalized nanoparticles for biomedical usage
Summary
Since its discovery in 1974, surface-enhanced Raman spectroscopy (SERS) has become a widely used analytical technique offering many advantages over other techniques such as FT-IR spectroscopy, UV-visible-near infrared (UV–vis-NIR) absorption, X-ray photoelectron spectroscopy, mass spectrometry, etc. The preparation of silver nanoparticles (AgNPs) is commonly done by reducing the silver ions of a precursor in a solution, usually aqueous media, and preventing particle growth by utilizing stabilizing agents such as surfactants and polymers. In this line, efficient methods of AgNP synthesis have been developed, i.e., the chemical reduction of silver salt solution by a reducing agent such as citrate, NaBH4, hydrazine, and hydroxylamine hydrochloride [7,8,9]
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