Abstract
The idea that antidepressants may be useful in the treatment of chronic pruritus appeared sometime in the 1990s. Although Zylicz et al. published a report in 1998 involving a series of patients suffering from various types of pruritus who responded to paroxetine,1 Browning et al.2 reported in 2003 on a group of 32 patients with primary biliary cirrhosis, also suffering from pruritus and having been observed for a mean of 7.5 years. In six out of seven patients who had been given sertaline initially for the treatment of depressive symptoms pruritus unexpectedly improved considerably, and in three of those subjects it completely disappeared.
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