Abstract
Medial olivocochlear (MOC) efferent neurons are located in the superior olive of the brainstem and form a sound evoked feedback loop that inhibits cochlear amplification via suppression of outer hair cell (OHC) electromotility. MOC neurons putatively receive a diverse range of synaptic input from various auditory and non-auditory brain regions. Given the proposed role of these neurons in context dependent tasks such as selective attention, we are interested in investigating the non-auditory modulation of MOC activity by the neurotransmitter serotonin (5-hydroxytryptamine, 5-HT). We used the ChAT-IRES-Cre;tdTomato mouse model to identify cholinergic MOC neurons in the brainstem. Immunohistochemical data have validated serotonergic terminals in apposition to both retrogradely labeled and genetically identified MOC neurons in mouse. During patch-clamp recordings from MOC neurons, exogenous application of serotonin increased neuron excitability by increasing action potential (AP) firing rate and decreasing both rheobase and AP threshold. Additionally, serotonin reduced the stimulation required to evoke a given AP firing rate in MOC neurons. These data will aid in our understanding of central auditory processing and how factors such as mood and attention are involved in modulating MOC responses in complex listening situations such as in the presence of background noise.
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