Abstract
Adaptive decision-making to eat is crucial for survival but in anorexia nervosa, the brain persistently supports reduced food intake despite the physiological need to consume food. How the brain persists in reducing food intake sometimes even to the point of death despite the evolution of multiple mechanisms to ensure survival by governing adaptive eating behaviors remains mysterious. Food intake is a conserved behavioral trait between all species and involves numerous biological systems including the old phylogenetically serotonergic system. The present review focuses on anorexia and the implication of specific serotonin (5-HT, 5-hydroxytryptamine) receptors in food intake. In this context, we found that an early restrictive food intake due to stress, critically engages goaldirected (decision-making) systems upon the control of the serotonin 5-HT4 receptors, supporting that an early food restriction may first protect from depressive-like states but could become a deadly dependence. Finally, in the face to environmental challenges, an initial protective and beneficial adaptive response could become a pathologic dependence.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.