Pediatria. Journal named after G.N. Speransky | VOL. 101
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СЕРОПРЕВАЛЕНТНОСТЬ АНТИТЕЛ К SARS-CoV-2 У ДЕТЕЙ НА ФОНЕ ЭПИДЕМИИ COVID-19 В РОССИЙСКОЙ ФЕДЕРАЦИИ

Publication Date Jun 17, 2022

Abstract

Objective: to study the seroprevalence of SARS-CoV-2 antibodies (AB) in children in the 2nd year of the COVID-19 pandemic in Russia. Materials and methods: prospective cohort study. The seroprevalence research was conducted among 3670 children aged 1 to 17 y/o from 26 modelling regions of Russia (that have been participating earlier in the five stages of seromonitoring during 2020-2021). The serological testing was carried out in December, 2021. The work was carried out according to a unified methodology set by the Russian Federal Service for Supervision of Consumer Rights Protection and Human Well-Being with the Pasteur Institute of Epidemiology and Microbiology (Saint Petersburg, Russia). The plasma was obtained from 3 ml of venous blood, in which the level of AB to nucleocapsid (NC), and the SARS-CoV-2 receptor-binding domain (RBD) was determined by immunoferment method using reagents for qualitative and quantitative analysis. Results: the analysis of AB seroprevalence to NC and RBD showed the statistically significant increase in the share of seropositivity to RBD in children of all modelling regions (p<0.05). The most seropositive volunteers contained low levels of AB: 31.3-125.6 BAU/ml NC and 22.6-220 BAU/ml RBD. An increase in the level of AB to NC and RBD was accompanied by a decrease in the percentage of seropositive patients. Evaluating the contribution of children to the level of humoral immunity, convalescents (had been ill shortly before the examination), the “anamnesis” (had been ill at previous stages of se...

Concepts

Receptor-binding Domain Asymptomatic Cases Of COVID-19 Nucleocapsid Ml Of Venous Blood Level Of Immunity Low Levels Of Antibodies Antibodies Seropositive Volunteers Consumer Rights Maximum Contribution

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No potential conflict of interest was reported by the authors. The conception and design of the study, acquisition of data, analysis and interpretatio...

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