Abstract
Background: Transfusion safety is a major concern in medical practice. Hepatitis E is a potential threat among transfusion-transmitted infections. In resource poor settings and in endemic countries, parenteral transmission can occur at an increased rate and leads to subclinical infection. Currently Hepatitis E virus screening is not mandatory in many countries. This can possibly endanger the population. Methods: We aimed at estimating the seroprevalence of HEV antibodies (IgG) among healthy blood donors in Chennai, South India. A prospective study was conducted among 142 blood donors from January 2016 to November 2016 in a tertiary care teaching hospital. Serum anti HEV IgG antibody was detected by Enzyme Linked Immuno Sorbent Assay (ELISA). Results: Out of 142 samples, 19/142 (13.38%) showed positivity for IgG antibodies for HEV. Conclusion: This study showed the importance of screening for HEV, as there is increased rate of positivity among the blood donors in our study population. DOI: 10.21276/APALM.1370
Highlights
Hepatitis E is an enterically transmitted infectious virus, which causes acute self-limiting hepatitis.[1]
In a study conducted among blood donors in Pune, 1.5% of Hepatitis E virus (HEV) RNA was estimated during the year 2000 and 3.7% during the year 2004.[5,6] Blood transfusions are carried out in critically ill cases that include solid organ transplantation, pregnancy, hematological disorders and neoplasm
We aimed at estimating the seroprevalence of HEV IgG antibodies among healthy blood donors in our tertiary hospital, Chennai, South India
Summary
Hepatitis E is an enterically transmitted infectious virus, which causes acute self-limiting hepatitis.[1]. It was estimated that 80,000 to 1,00,000 HEV infections had occurred due to transfusion in England in 2013, with seroprevalence rate of 6.8% and annual incidence rate of 0.35%.[4] Studies in developing countries like India are very limited and only little evidence is available till now. Though acute morbidity due to transmission of HEV infection through blood transfusion is rare and supporting evidences are still lacking, studies need to be explored in all developing countries to know the real burden of transfusion transmitted HEV infections.[7] we aimed at estimating the seroprevalence of HEV IgG antibodies among healthy blood donors in our tertiary hospital, Chennai, South India. Materials and Methods: We aimed at estimating the seroprevalence of HEV antibodies (IgG) among healthy blood donors in Chennai, South India. Conclusion: This study showed the importance of screening for HEV, as there is increased rate of positivity among the blood donors in our study population
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