Abstract
Morphological changes were studied in the glandular stomach of rats with carcinogenesis induced by N-methyl-N′-nitro-N-nitrosoguanidine (NG). NG was given to 100 rats in their drinking water at the level of 167 μg/ml for 40 weeks and then 84 μg/ml until the end of the experiment. Rats were killed periodically and histological changes in the glandular stomach were examined. Three types of glandular proliferation were distinguished: regenerative glandular hyperplasia, adenomatous hyperplasia, and adenocarcinoma. These lesions were mainly in the antrat region of the stomach. After atrophy and erosion of the mucosa, regenerative glandular hyperplasia, with irregular glands at the margins of erosions, developed in the 3d–5th week, and these lesions persisted for the rest of the experiment. Adenomatous hyperplasia, characterized by excessive glandular proliferation with scanty cellular atypism, developed in the 20th week, and these lesions were found in the middle of the experimental period. Adenocarcinoma, consisting of excessive glandular proliferation with cellular atypism, appeared in the 30th week and gradually invaded to the submucosa, the muscularis propria, and the serosa. After the 60th week, almost all rats had adenocarcinoma with serosal invasion.
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