Abstract
A new virus, human herpesvirus 8 (HHV-8), has recently been associated with Kaposi sarcoma (KS), body cavity—based lymphoma, and Castleman disease.<sup>1</sup>Using polymerase chain reaction (PCR) with the KS330<sub>233</sub>primers, HHV-8 sequences were detected in an angiosarcoma specimen from a 63-year-old woman who was seronegative for the human immunodeficiency virus,<sup>2</sup>in 4 cases of angiolymphoid hyperplasia and eosinophilia,<sup>3</sup>in 7 of 24 angiosarcomas, and in 1 of 20 hemangiomas.<sup>4</sup>Other authors<sup>5,6</sup>have failed to demonstrate evidence of HHV-8 in various vascular lesions from Japanese or Chinese patients, including hemangiomas, hemangiopericytomas, pyogenic granulomas, and cutaneous or visceral angiosarcomas. However, a lack of test sensitivity could account for these negative results since they were obtained from parraffin-embedded tissues using a simple PCR. Taking into account these controversial findings, our aim was to obtain further data on the presence of HHV-8 in benign or malignant non-KS vascular
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