Abstract
Human tRNA Glu CUC has been isolated by direct hybridization of the tRNA to 28S ribosomal RNA. We now report the isolation of mouse tRNA Glu CUC using the same procedure. Partial sequence analysis of the mouse tRNA shows that it is identical to the human tRNA and to a cloned rat tDNA Glu CUC sequence. This mouse tRNA Glu CUC, however, differs by one nucleotide from a previously cloned mouse tDNA Glu CUC sequence, suggesting that the tDNA may be a pseudogene. Further evolutionary comparison of these and other glutamate tRNAs and tDNAs has provided evidence to suggest that two other tDNA Glu sequences arose by mutation of functional tRNA Glu genes such that their anticodon sequences were converted from one glutamate isoacceptor to the other. These tDNA sequences may also represent pseudogenes.
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