Abstract
An anion-exchange high performance liquid chromatographic separation of technetium hydroxyethylidene diphosphonate (Tc-HEDP) complexes has been developed. Samples were prepared by the reduction of TcO/sub 4//sup -/ in the presence of HEDP with NaBH/sub 4/. Samples contained millimolar concentrations of /sup 99/Tc carrier and nanomolar concentrations of the ..gamma..-emitting /sup 99m/Tc isotope. Three modes of detection were used: (1) single wavelength at 405 nm, (2) uv-visible rapid scanning from 250 to 600 nm, and (3) single channel radiometric scintillation. The chromatograms illustrate that these radiopharmaceutical analogues consist of mixtures of at least seven Tc-containing species of unknown oxidation state, central metal configuration, and coordination environment. The distribution of components in these mixtures is dependent on reaction time and the presence of molecular oxygen. 9 figures, 1 table.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
