Abstract
Steroidal saponins are the major bioactive constituents in Paris Polyphylla. In the present study, we developed a novel analysis method for separation and characterization of steroidal saponins in Paris Polyphylla extract using high-performance liquid chromatography electrospray ionization time of flight mass spectrometry (HPLC/ESITOFMS) and ion trap mass spectrometry (HPLC/ITMS). A total of 30 steroidal saponins in Paris Polyphylla extract were identified effectively according to their accurate mass measurements, molecular formulae, and various characteristic fragmentation behaviors. It is concluded that the established analysis method is sensitive, rapid, and practical. Additionally, it will provide help for further quality control and pharmacological mechanism study of Paris Polyphylla.
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