Abstract
TPS114 Background: For patients with breast cancer undergoing neoadjuvant systemic treatment (NST) the optimal timing of sentinel-node biopsy (SLNB) is unclear. While adequate axillary staging prior to NST could allow for a priori tailoring of systemic treatment, SLNB after NST could spare those patients from complete axillary dissection (AD), who are free of metastases in the axilla or convert from a positive (Npos) to a negative (Nneg) axillary status following NST. For these patients, however, the reliability of SLNB to predict the axillary status remains yet to be prospectively confirmed. Methods: The German SENTINA protocol, as a substudy of the German Geparquinto neoadjuvant trial of the AGO and the German Breast Group (GBG), is a 4-arm prospective multicenter case control study designed to examine the role of SLN in patients undergoing NST. Study objectives are: 1) to compare the detection rate of SLNB before and after NST; 2) to evaluate the number of patients with involved nodes despite being cli...
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