Abstract
Pairing specific LTD (PSD) is produced by paired parallel fiber (PF) and climbing fiber (CF) stimulation and requires Ca 2+ elevation. CF or PF activation cause Ca 2+ increase through voltage dependent channels and IP3 induced Ca 2+ release, respectively. We developed a model of Ca 2+ dynamics in Purkinje cell spines to investigate why paired PF–CF activation is necessary for PSD. Simulations show a supralinear increase of the Ca 2+ signal if the CF input occurs in a restricted time interval following the PF input. Ca 2+ buffers significantly contribute to this phenomenon. This mechanism may be involved in the requirement of temporal specificity in classical conditioning.
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