SENSITIVITY OF GRAM-NEGATIVE CAUSATIVE AGENTS OF INFECTIOUS INFLAMMATORY DISEASES OF SOFT TISSUES OF THE FACIAL REGION TO ANTIBIOTICS

Abstract

Today timely monitoring of the sensitivity of gram-negative non-fermenting bacteria taken from various sites of the human body to antibiotics is extremely important in the way of stopping and overcoming significant spread of antibiotic resistance. The aim of this study is to determine the sensitivity of gram-negative causative agents of infectious inflammatory diseases of soft tissues of the face region to antibiotics. Materials and methods. The study included 25 clinical isolates of the genus Acinetobacter and 22 clinical isolates of the genus Pseudomonas. Determination of the sensitivity of microorganisms was carried out using the disc diffusion method and the method of double serial dilutions in a liquid nutrient medium in accordance with the recommendations by EUCAST. Results. The level of sensitivity of representatives of genus Acinetobacter to imipenem and meropenem did not exceed 29.6%. The lowest sensitivity was found to fluoroquinolones and the highest sensitivity was revealed to aminoglycosides. Pseudomonas spp. showed low sensitivity to penicillins and cephalosporins. The similarity of the sensitivity results of Pseudomonas spp. to carbapenems imipenem and meropenem was detected. Along with this, testing the sensitivity of pseudomonads to protected carbapenems showed a better result. Moreover, clinical isolates of Pseudomonas spp. showed high resistance to fluoroquinolones and aminoglycosides. Conclusion. Acinetobacter spp. and Pseudomonas spp., isolated from patients with infectious and inflammatory diseases of the soft facial tissues have a rather low sensitivity to antibacterial drugs of various groups. Acinetobacter spp showed the highest sensitivity to gentamicin and amikacin. Pseudomonas possesses the highest sensitivity to cefiderocol, imipenem relabactam and meropenem verabactam.