Abstract
Abstract Cocaine metabolism produces two major metabolites, benzoylecgonine (BE) and ecgonine methyl ester (EME) (1-4). BE is the metabolite ordinarily used to identify cocaine misuse in urine (5). However, determination of EME and cocaine in urine can provide valuable and important forensic information as to the source of BE and the time of cocaine ingestion (4-7). Laboratories should therefore be able to provide information on EME and cocaine when requested, in addition to BE. We have already described a sensitive and selective procedure for EME analysis in urine (8). We now present a rapid and sensitive procedure for the identification and quantification of cocaine in urine.
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