Abstract
A highly sensitive electrochemiluminescence (ECL) aptasensor for lincomycin (Lin) detection was designed based on a novel self-accelerated ECL luminophore of Ag3PO4-Ti3C2 nanohybrids. The Ag3PO4-Ti3C2 nanohybrids demonstrated prominent ECL performances with K2S2O8 as co-reactant, and the Ti3C2 as co-reaction accelerator, which catalyzes K2S2O8 into more active radicals and inducing a tremendous amount of excited-state luminophores. Besides, it can be used for loading aptamer molecules owing to its large surface area. Given these attributes, a self-accelerated ECL aptasensor for Lin detection was constructed based on the effect of target induced aptamer dissociating. Under optimized conditions, the ECL aptasensor exhibited wide linear relationship of 1.0 × 10−4 nmol/L to 1.0 × 102 nmol/L, low detection limit of 6.17 × 10−5 nmol/L (S/N = 3) and good stability and reproducibility for Lin detection. The aptasensor was successfully applied for the Lin detection in milk and water samples, implying immense potential in real applications.
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