Abstract
AimThe aim of the present study is to identify and optimize the self emulsifying regions of different compositions of various oils, surfactants and co-surfactants and its prototype. MethodsThe ternary phase diagram was constructed using series concentrations of oils, surfactants and co-surfactants to recognize the self emulsifying region. The selected self emulsifying compositions were evaluated and optimized using self emulsification time, robustness to dilution and globule size analysis. ResultsThe percentage of compositions of surfactants and co-surfactants with the oil phase plays a significant role for the formation of nano sized self emulsion. ConclusionThe prepared self emulsified prototype was ready to incorporate many poorly soluble drugs to improve its solubility and bioavailability as well.
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