Abstract
Self nano emulsifying drug delivery systems (SNEDDs) gained much attention in the last decades since, such systems considered one of the most favorable and efficient approaches to enhance solubility, increase drug absorption and hence, enhance its oral bioavailability of poorly water soluble (lipophilic) drug moieties. Owing to their unique properties and advantages over the other conventional dosage forms, many literatures investigate the change physicochemical properties, pharmacokinetic and pharmacodynamics of self emulsifying formulation compared to both pure drug and its conventional dosage form and always reported significant improvement using SNEDDs. This review discus the composition, advantages and mechanism of action of liquid SNEDDs and some techniques used for solidification of liquid formulations to overcome its drawbacks.
Highlights
RECORDS OF PHARMACEUTICAL AND BIOMEDICAL SCIENCESSelf - Emulsifying Drug Delivery System: A Novel Approach for Oral Delivery of Poorly Water Soluble Drugs
Despite of being the most favorable administration route, it is restricted for drugs with sufficient permeability through gastric mucosa and water solubility
The drug molecules incorporated in Self-nanoemulsifying drug delivery systems (SNEDDs) must be partitioned within the fine o/w emulsion droplets formed upon contact with aqueous fluids in (GIT) to avoid poor in-vivo performance resulted from precipitation of drug and this can be avoided via using high concentration of surfactants(Wei, Ye et al 2012)
Summary
Self - Emulsifying Drug Delivery System: A Novel Approach for Oral Delivery of Poorly Water Soluble Drugs. Ahmed R.Gardouh a,b, Ahmed M.Nasef c*, Yasser Mostafad, Shadeed Gad a aDepartment of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Suez Canal University, Ismailia, 41522, Egypt; bDepartment of Pharmacy, Faculty of pharmacy, Jadara University, 21110 Irbid, Jordan; c Production department, Medical Union Pharmaceutical (MUP) Co., Ismailia, 41617, Egypt; dDepartment of Pharmacology and Toxicology, Faculty of Pharmacy, Suez Canal University, Ismailia, 41522, Egypt
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