Abstract

Raynaud phenomenon (RP) in connective tissue disease (CTD) can be resistant to oral vasodilator therapy, resulting in uncontrollable digital ischemia. Intravenous (IV) prostanoids are often used, but the benefit can be transient and not all patients respond. Selexipag is an orally active selective IP-type prostanoid receptor agonist used in pulmonary arterial hypertension. We describe 2 patients where selexipag significantly reduced digital ischemia after failure of other oral vasodilating agents. Subject 1 with undifferentiated CTD had impressive healing of her fingers (Figure 1) and subject 2 with systemic sclerosis (SSc) had a …

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