Abstract
Selenium (Se) incorporated mesoporous bioactive glasses (MBG) have been prepared using the traditional sol–gel method. The Se/MBG particles retain typical characteristics of mesoporous structures (SBET=230–250m2/g and DP=4.0–4.1nm) and excellent hydroxyapatite formation ability when soaked in simulated body fluids for 3 days. To investigate their delivery properties further, doxorubicin (DOX) was selected as a model drug. The results indicate that the Se/MBG particles exhibit sustained DOX delivery, and controlled release mechanism by Fickian diffusion according the Higuchi model. Based on a favorable in vitro bioactive response and controllable DOX delivery, this material is a promising candidate for application in malignant bone tumor therapy.
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