Abstract
The Methylene Blue Reduction Time (MBRT) of human plasma, introduced in 1947 as a chemical test for malignancy, was later found to be insufficiently specific or accurate for routine cancer diagnosis. However, the MBRT of human plasma samples is inversely related to the total plasma selenium content ( r = −0.56; P = 0.002). The MBRT is also inversely related to plasma pH, but is insignificantly affected by observed variations in plasma sulfhydryl, copper, iron, and cobalt levels ( P = 0.05). The diminished plasma selenium levels observed in malignant disease support the suggestion that selenium is a cancer protecting agent; statistical analysis demonstrates that those states of the United States with elevated selenium levels in forage crops and grains have lowered cancer mortality ( r = −0.467; P = 0.01). These results are supported by statistical data and animal carcinogenesis experiments of other investigators.
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