Abstract
The Merrifield solid phase synthesis turned out to be the key method to put into practice many of the concepts I conceived during my scientific work concerned with the systematic empirical search for biologically active synthetic compounds. This is true for the first combinatorial “filter discs” method invented for the simultaneous synthesis of oligonucleotides, as well as for all following methods, then dedicated to peptide and later to small molecule synthesis, such as the “cut and combine” method, the “SPOT synthesis” method and the recent “SC2” method for the generation of compound repertoires in the micro-array format.
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