Abstract
Neurology Nerve junctions (or synapses) electrically transmit (or fire) information from one neuron to another. Many diseases are characterized by misfiring synapses. Finnema et al. have developed a noninvasive imaging approach that targets the synaptic vesicle glycoprotein 2A. Now human synapses can be observed firing in the living brain. In the brains of patients with epilepsy, synaptic density was found to be asymmetric, which is consistent with damage to certain regions. Thus, this imaging method permits monitoring of synaptic loss in the brains of people with various neurological and psychiatric diseases, which could contribute prognostic information. ![Figure][1] Positron emission tomography image of a subject with epilepsy PHOTO: FINNEMA ET AL. Sci. Transl. Med. 8 , 348ra96 (2016). [1]: pending:yes
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