Abstract
Thirty-two patients with familial dwarfism were examined. Stimulated and spontaneous secretion of growth hormone was studied in all of them. Stimulated secretion was assessed in two standard pharmacologic tests, spontaneous one was examined during the first 3 h of night sleep. Analysis of the results showed an irregular pattern of growth hormone secretion. Disorders of the hormone secretion of the neurosecretory dysfunction type with a partial deficit of growth hormone were revealed in the majority (20 out of 32) patients, which may be the cause of growth retardation. In twelve patients the levels of both stimulated and spontaneous secretion were normal.
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