Abstract

The first suggestion that the secretion of pancreatic juice is influenced by the presence of acid in the duodenum was made by Dolinski (1) in 1895. Pawlow (2) taught that the activity of the pancreas is due to the secretory nerves it receives through the vagus and sympathetic. Popielski (3), in an endeavor to reconcile the action of acid in the small intestine with the idea of nervous control over pancreatic activity, advanced the explanation that the secretion arose from a peripheral reflex through scattered ganglia of the panGreas situated mostly near the duodenum. In this he was confirmed by Wertheim,er and Lepage (4). However, during the past twenty years an ever-growing mass of evidence has been accumulating in support of the idea elaborated by Bayliss and Starling (5, 6), founded on the earlier observation of Dolinski, to the effect that acid in the duodenum produces a hormone, secretin,

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