Abstract
Cocoa powder is a product derived from the beans of the Theobroma cacao tree, which is considered a good source of fiber (26%–40%), proteins (15%–20%), carbohydrates (about 15%) and lipids (10%–24%; generally, 10%–12%).[...]
Highlights
The aim of this study was to assess the vascular benefits of a dark chocolate intake program, over the central arterial hemodynamics, in healthy and young individuals
This study shows that acute cocoa flavanols (CF) intake increases cerebral blood flow (CBF) (Hbtot, HbO2) during a cognitive test (CT), but does not result in an improved cognitive performance
Due to the fact that the C10 diet had a higher impact on the urinary metabolic profile than the CF diet, it is likely that other cocoa compounds, rather than cocoa fiber, are responsible for these effects
Summary
With regard to general function health claims, in Europe more than 44,000 proposals were made, from which the European Commission prepared a list of about 4600 submitted to EFSA for scientific evaluation. Cocoa treatment reduced the expression of hepatic pro-inflammatory markers (monocyte chemoattractant protein 1 and macrophage inflammatory protein 1a), but increased expression of hepatic markers of alternative (anti-inflammatory) macrophage activation (interleukin 10 and CD163) compared to HF-fed obese controls. Cocoa treatment reduced hepatic lipid peroxidation by 57% compared to HF-fed controls, indicating reduced oxidative stress These effects were related to an increase in the expression of Sirt, an important mitochondrial redox regulator, as well as the expression and activity of manganese superoxide dismutase and glutathione peroxidase. Our results demonstrate that the beneficial effects of cocoa supplementation on non-alcoholic fatty liver disease may be mediated by increases in mitochondrial biogenesis and related antioxidant response signaling.
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
