Abstract
BackgroundSebaceous carcinoma is a rare cancer, and little is known about its current epidemiology and treatment. This is particularly true for sebaceous carcinomas of the trunk and extremities. ObjectiveWe present a database analysis of sebaceous carcinoma cases to further delineate demographics, location, tumor characteristics, and treatment modalities among patients diagnosed with these tumors. MethodsThe National Cancer Database (NCDB) was queried for cases of sebaceous carcinoma between 2004 and 2016. 3211 cases were analyzed for descriptive and comparative statistics. Results26% of sebaceous carcinomas were found on the trunk and extremities. Tumors on the trunk and extremities were more likely to be larger than tumors on the head and neck, with 8% being greater than 50mm (P<.001). Tumors on the trunk and extremities were more likely to be well differentiated (P<.001) and have fewer lymph node metastases (P<.001). Surgery was the primary treatment modality for tumors, followed by radiotherapy and rarely chemotherapy. ConclusionsSebaceous cancer is a poorly understood entity. We demonstrated that trunk and extremity tumors tend to be larger and more differentiated than those of the head and neck. Treatment practices are varied at this time, but surgery is the primary modality.
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