Abstract
The article presents the analysis of vitamin D levels in children of various age groups residing in Moscow and assesses the seasonality of vitamin D variations in this population group. In this work, the results of 25 (ОН) D level measurement in 1041 children in the age from 1 month to 18 years collected in the period since 2012 to 2015 have been analyzed. In accordance with the analysis, in spite of the age, the high percentage of vitamin D insufficiency was detected among children in Moscow. The generally accepted optimum level of vitamin D metabolite – calcidiol in blood (>30 ng/ml) was observed only in the small part of the study participants (26%), while the larger part (74%) had the insufficient level of vitamin D of various intensity: 28% - insufficiency (20-29 ng/ml), 33% - deficiency (<20 ng/ml), 13% - severe deficiency (<10 ng/ml). With the age, the insufficiency level was more pronounced. The seasonality analysis showed the significant difference of vitamin D level between summer and winter seasons (p=0.01). The greatest decrease of vitamin D levels was observed in winter (median level of 25(ОН)D 17.0 (11.0; 25.0) ng/ml). In summer months, the relative calcidiol gain was fixed (median – 22.9 (18.0; 33.0) ng/ml) which, however, did not achieve the normal level. Children and, in particular, adolescents residing in Moscow need year-round hypovitaminosis D prophylaxis with cholecalciferol products.
Highlights
There is a big number of fundamental and clinical studies related to various biological effects of vitamin D and its favorable health effect
In accordance with the data obtained during the study, the prevalence of vitamin D deficiency in various age groups of the Moscow pediatric population remains very high
It should be especially noted that the sufficient calcidiol level in blood was observed only in the group of patients of the first year of life, while already from the age of two years, the larger part of the study participants had vitamin D insufficiency and its prevalence only increases with the age
Summary
There is a big number of fundamental and clinical studies related to various biological effects of vitamin D and its favorable health effect. The main differential characteristic of vitamin D in comparison with other vitamins is its steroid chemical structure and presence of the specific receptor to its active metabolite 1.25(OH)2D in various body tissues It allows to consider vitamin D as a steroid hormone. The wide range of vitamin D effects on human health, in particular health of a child that acutely needs vitamin D on each stage of his/her development, have been of great interest for scientists and physicians already for several decades. In spite of this fact, the prevalence of D-deficient status remains currently rather high and requires decisive steps to overcome it. Study aim: to examine vitamin D provision in children and detect its relationship with the age group and year season among the Moscow residents
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