Abstract
Tissue injuries occur frequently in daily life, but remain a challenge to treat in clinical medicine. Significant progress has been made in designing materials capable of directing endogenous cells to promote tissue regeneration. However, few studies have described a material that simultaneously promotes endogenous cell recruitment, immunomodulation, angiogenesis, soft tissue healing and bone tissue regeneration. Small intestinal submucosa (SIS) membrane possesses good biocompatibility and a precise spatial structure. The stromal-derived factor-1 (SDF-1) plays an important role in recruiting resident or circulating stem cells. In this work, the derived SDF-1α peptide was modified with a collagen-binding peptide to specifically tether to the SIS membrane. During the initial phase of tissue repair, pSIS@SDF-1α promoted cell recruitment and M2 polarization of macrophages. Subsequently, pSIS@SDF-1α promoted angiogenesis as well as osteogenic differentiation of bone marrow MSCs. The results of in vivo experiments demonstrated that pSIS@SDF-1α promoted soft tissue wound repair and regenerative repair of defective bone tissue. In conclusion, these findings may have important implications for in situ tissue regeneration by orchestrating endogenous cell recruitment and host responses.
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