Abstract
Background: Cancer patients are at risk of developing some level of psychological dysregulation, depending on a series of variables related to the tumor, the environment, and the patient. In this context, it becomes important to define the difference between psychological and psychiatric disorder and to study its prevalence. The primary endpoint of this study is to evaluate the prevalence of psychiatric disorders in a sample of Portuguese patients with metastatic breast cancer and assess the relationship between these disorders and the characteristics of the oncological disease. Methods: Cross-sectional, single-center study with female patients diagnosed with metastatic breast carcinoma and under palliative treatment between November 2020 and May 2021. Psychiatric disorders were screened by applying and filling-out the MMSE, HADS, BSI, and WHOQoL-Bref instruments at the outpatient daycare unit when patients were present for treatmen. Results: A total of 91 female patients were included, median age 59.79 years. None of the patients had cognitive impairment (MMSE). HADS scale: 18.7% of the patients scored for anxiety and 17.6% for depression. The anxiety subscale score of > 8 (HADS) was related to ovarian function suppression (p<0.001), neoadjuvant therapy (p<0.001), and type of second-line of palliative treatment (p=0.024). The depression subscale score >8 (HADS) was related to the type of surgery performed (p= 0.022), molecular subtype of the tumor (p=0.020), and occurrence of grade 3-4 toxicities in the first (p=0.018), and third-line treatments (p=0.031). Conclusion: The screening of psychiatric disorders through the application of these scales by the medical oncology team may be able to aid in diagnosis and potentially lead to psychiatric referral and intervention at an earlier stage.
Highlights
Cancer is the second leading cause of death worldwide, after cardiovascular disease.[1]
The application and filling-out of the various scales (Mini Mental State Examination (MMSE), Hospital Anxiety and Depression Scale (HADS), BSI, and WHOQoL-Bref instruments) was conducted by the first author before treatment in order to minimize bias that could be developed in the post-treatment period
Regarding gynecological and obstetric history, menarche was between 10 and 12 years old in 58.3%; 69.2% of patients had used oral contraceptives at some point in their lives; 96.7% of patients had children and 64.8% had their first child before age 30; 75.8% of patients were postmenopausal or under ovarian function suppression at the time of data collection
Summary
Cancer is the second leading cause of death worldwide, after cardiovascular disease.[1]. Cancer patients are at risk of developing some level of psychological dysregulation, depending on a series of variables related to the tumor, the environment, and the patient In this context, it becomes important to define the difference between psychological and psychiatric disorder and to study its prevalence. The depression subscale score >8 (HADS) was related to the type of surgery performed (p= 0.022), molecular subtype of the tumor (p=0.020), and occurrence of grade 3-4 toxicities in the first (p=0.018), and third-line treatments (p=0.031)
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