Abstract
A screening procedure for adrenocortical insufficiency, utilizing (synthetic a 1-24 adrenocorticotropic hormone [ACTH] and a cortisol-binding globulin technique for serum cortisol, has been evaluated in normal subjects and in patients with primary and secondary adrenal insufficiency. Cosyntropin is injected by vein, and a serum cortisol concentration 60 minutes later is compared with a sample removed just prior to the cosyntropin administration. A clear separation of normal subjects from those with adrenal insufficiency is achieved.
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