Saxitoxin effects on the levels of neurotransmitters in different rat brain regions

Abstract

Event Abstract Back to Event Saxitoxin effects on the levels of neurotransmitters in different rat brain regions Rosa C. Cervantes1*, Rafael Duran1, Lilian F. Faro1 and Miguel Alfonso1 1 Vigo University, Department of Functional Biology and Health Sciences, Spain The health-related environmental relevance of freshwater and marine phytoplankton is principle related to their ability to produce a wide range of toxins. These toxins are dangerous to different life form including man. Saxitoxin (STX) is one of several related toxins that cause paralytic shellfish poisoning (PSP). These toxins are produced by different genus of dinoflagellates (e.g. Alexandrium catenella, Alexandrium tamarense, Karenia brevis). They are powerful neurotoxic compounds which blocks the sodium channels voltage sensitive, entailing to the appearance of the main symptoms of the poisoning by PSP: Muscular paralysis and respiratory depression. Due to the wide geographical distribution of dinoflagellates and its implications in harmful algae bloom, an assessment of the potential risk to human health is needed. The aim of this study was to know the effect that the systemic administration of 5 and 10 μg/Kg STX doses (body weight) produce on the levels of neurotransmitters (biogenic amines) in different male rat brain regions. After three time intervals, 30, 60 and 120 min for the first dose and 30 min for the second one, animals were sacrificed by cervical dislocation. The results obtained showed that STX produced alterations in the levels of neurotransmitters. Conference: 11th Meeting of the Portuguese Society for Neuroscience, Braga, Portugal, 4 Jun - 6 Jun, 2009. Presentation Type: Poster Presentation Topic: Neuronal Communication Citation: Cervantes RC, Duran R, Faro LF and Alfonso M (2009). Saxitoxin effects on the levels of neurotransmitters in different rat brain regions. Front. Neurosci. Conference Abstract: 11th Meeting of the Portuguese Society for Neuroscience. doi: 10.3389/conf.neuro.01.2009.11.124 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 11 Aug 2009; Published Online: 11 Aug 2009. * Correspondence: Rosa C Cervantes, Vigo University, Department of Functional Biology and Health Sciences, Vigo, Spain, rosacarminac@yahoo.com Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers Rosa C Cervantes Rafael Duran Lilian F Faro Miguel Alfonso Google Rosa C Cervantes Rafael Duran Lilian F Faro Miguel Alfonso Google Scholar Rosa C Cervantes Rafael Duran Lilian F Faro Miguel Alfonso PubMed Rosa C Cervantes Rafael Duran Lilian F Faro Miguel Alfonso Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page.