Abstract
The effect of exogenous cholecystokinin and gastric loads of substances shown to release endogenous cholecystokinin were investigated in rats. Intraperitoneal injection of cholecystokinin and caerulein produced a significant suppression of food but not water intake. Phenylalanine (the L but not the D isomer), egg yolk and 0.1 N HCl but not MgSO 4 depressed feeding in the fasted rats. This satiety effect does not seem to be mediated via the vagus nerve, as suppression of food-intake was observed after subdiaphragmatic vagotomy. Blocking of pancreatic enzyme secretion does not prevent cholecystokinin-induced satiety.
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