Sarcopenia as a Risk Factor for Cognitive Deterioration in Community-Dwelling Older Adults: A 1-Year Prospective Study

Abstract

ObjectiveThe purpose of this 1-year prospective study was to determine whether sarcopenia is an independent risk factor of cognitive deterioration in community-dwelling older adults. Study DesignOne-year prospective study. SettingJapanese community. ParticipantsA total of 131 community-dwelling older adults aged 65 years and older participated in this study. MeasurementsWe defined sarcopenia using the diagnostic algorithm recommended by the Asian Working Group for Sarcopenia, and the participants were classified into the sarcopenia and normal groups according to this definition. The participants' cognitive functions were assessed using the Mini-Mental State Examination (MMSE) during pre- and postdata collection (after 1 year). ResultsThe rate of change in pre- and post-MMSE scores during the follow-up term was significantly different between the 2 groups (normal group, −0.32 ± 8.39%; sarcopenia group, −5.86 ± 5.16%; P = .002). The analysis of covariance, adjusted for demographic data and the pre-MMSE scores, showed a significant change in the MMSE scores between the normal and sarcopenia group (F = 9.30, P = .003). Furthermore, in the multivariate logistic regression analysis, the cognitive function was significantly more likely to deteriorate (defined as a loss of at least 2 points of MMSE) in the sarcopenia group during the follow-up term (odds ratio: 7.86, 95% confidence interval: 1.53–40.5). ConclusionsSarcopenia was identified as an independent risk factor of cognitive deterioration in community-dwelling older adults during the 1-year study period.