Abstract
Salivary gland-like breast tumors are rare and diagnostic challenging tumors. The tumors show similar histological features and molecular diagnostic alterations to their counterpart in the salivary glands, except for acinic cell carcinomas. Some tumors show a complex epithelial and myoepithelial composition (pleomorphic adenoma, basal cell adenoma, adenomyoepithelioma, and adenoid cystic carcinoma). In contrast, others are predominantly epithelial (polymorphous adenocarcinoma, mucoepidermoid carcinoma, secretory carcinoma, and acinic cell carcinoma). Some tumors are benign, while others are carcinomas of low malignant potential. Occasional cases show high-grade transformation and aggressive behavior, with distant metastases.Despite being triple-negative tumors, they do not require conventional chemotherapy in most instances, except for cases with high-grade histology and metastases. Limited experience exists in metastatic secretory carcinomas with pan-NTRK inhibitor therapy, which is promising.
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