Abstract
A new benzhydryl-type protective groups for amides based on the concept of converting a stable protecting group into a labile one (safety-catch principle) are described. The p-substituted benzhydrylamine derivatives III(a, b), IV(a, b) are shown to be labile toward various acids but in their oxidized state - V(a, b), VI(a, b) exhibit the resistance to conditions commonly used for removal the Boc group. Independent removal of Boc or Fmoc groups, each in the presence of derivative VIa, is demonstrated by a synthesis of Pro-Leu-Gly-NH2. Some mechanistic aspects of deprotection reaction are discussed.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: Collection of Czechoslovak Chemical Communications
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
