Abstract
ObjectiveThe objective of this study was to determine the safety profile of methotrexate (MTX) therapy in patients with rheumatoid arthritisStudy designThis was a cross-sectional observational study.Place and duration of the studyThe study took place in the Division of Rheumatology, Lady Reading Hospital Peshawar, from May 2020 to August 2021.MethodologyA total of 411 patients with rheumatoid arthritis and receiving MTX in the dose of 10-20 mg/week for at least four months were included by consecutive sampling. All patients were followed for four months for the development of cytopenias, deranged liver function tests, renal function tests, fever, and gastrointestinal upsets. Data were recorded on a pro forma.ResultsThere were 237 (57.6%) females and 174 (42.4%) males. The female to male ratio was 1.4: 1. The average age of patients was 43.01 years + 17.1 SD with a range of 18-72 years. Gastrointestinal side effects were the most common, found in 49 patients (11.9%), followed by mucocutaneous side effects in 35 patients (8.5%) and fever (34 patients, 8.3%).ConclusionEvery one in three patients developed some adverse effect within six months of methotrexate therapy. Moreover, we conclude that gastrointestinal side effects were the most common side effects seen.
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