Abstract
BackgroundFluralaner (Bravecto™; Merck/MSD Animal Health) is a novel systemic ectoparasiticide for dogs providing long-acting flea and tick control after a single oral dose. Milbemycin oxime and praziquantel are routinely used to control Dirofilaria immitis and intestinal worm infections in dogs. The safety of concurrent use of fluralaner and a commercially available milbemycin oxime plus praziquantel combination tablet, in particular with regard to gastrointestinal symptoms, was investigated using oral doses at or above the maximum recommended rates.FindingsSome minor and transient clinical findings were observed during the study period; however, none of these was considered to be related to concurrent treatment with fluralaner and milbemycin oxime plus praziquantel, or to the use of either product alone.ConclusionsConcurrent treatment with fluralaner, milbemycin oxime and praziquantel is well tolerated in dogs.
Highlights
Fluralaner (BravectoTM; Merck/MSD Animal Health) is a novel systemic ectoparasiticide for dogs providing long-acting flea and tick control after a single oral dose
Concurrent treatment with fluralaner, milbemycin oxime and praziquantel is well tolerated in dogs
Throughout the 4-week study period, there were no findings related to the concurrent treatment with fluralaner and milbemycin oxime plus praziquantel, or to the treatment with milbemycin oxime plus praziquantel
Summary
Concurrent treatment with fluralaner, milbemycin oxime and praziquantel is well tolerated in dogs. Milbemycin oxime is active against larval and adult stages of intestinal nematodes as well as against larval blood stages of heartworm (Dirofilaria immitis). Dogs may concurrently be exposed to tick and flea infestations, heartworm infestations and intestinal worm infestations, veterinarians may choose to administer fluralaner concurrently with milbemycin oxime and praziquantel. For both products mild and transient gastrointestinal effects, like vomiting, inappetence, drooling and diarrhea, may occur after oral administration [2-4]. To confirm the safety of the concurrent use of fluralaner and milbemycin oxime plus praziquantel, in particular with
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