Safety and Efficacy of Soluble Guanylate Cyclase Stimulators in Patients with Heart Failure: A Systematic Review and Meta-analysis

Abstract

Background The utility of novel oral soluble guanylate cyclase (sGC) stimulators (vericiguat and riociguat), in patients with reduced or preserved ejection fraction heart failure (HFrEF/HFpEF) is currently unclear. Methods ultiple databases were searched to identify relevant randomized controlled trials (RCTs). Data on the safety and efficacy of sGC stimulators were compared using relative risk ratio (RR) on a random effect model. Results Six RCTs, comprising 5604 patients (2801 in sGC stimulator group and 2803 placebo group) were included. The primary endpoint (a composite of cardiovascular mortality and first HF-related hospitalization) was significantly reduced in patients receiving sGC stimulators compared to placebo [RR 0.92, 95% confidence interval (CI) 0.85-0.99, p=0.02]. The incidence of total HF-related hospitalizations were also lower in sGC group (RR 0.91, 95% CI 0.86-0.96, p=0.0009), however, sGC stimulators had no impact on all-cause mortality (RR 0.96, 95% CI 0.86-1.07, p=0.45) or cardiovascular mortality (RR 0.94, 95% CI 0.83-1.06, p=0.29). The overall safety endpoint (a composite of hypotension and syncope) was also similar between the two groups (RR 1.50, 95% CI 0.93-2.42, p=0.10). (Figure) By contrast, a stratified subgroup analysis adjusted by type of sGC stimulator and heart failure (vericiguat vs. riociguat and HFrEF vs. HFpEF) showed near-identical rates for all safety and efficacy endpoints between the two groups at a mean follow-up of 19 weeks. For the primary composite endpoint, the number needed to treat was 35, the number needed to harm was 44. Conclusion The use of vericiguat and riociguat in conjunction with standard heart failure therapy shows no benefit in terms of decreasing HF-related hospitalizations or mortality.